Abstract
The direct effects of droperidol, fentanyl, Innovar, meperidine, hydroxyzine, and a 1:1 combination of meperidine and hydroxyzine on myocardial contractility were determined utilizing isometrically contracting rabbit right ventricular papillary muscles and human atrial strips. In rabbit papillary muscles, no positive inotropic effects were found for any of these drugs, but each drug except fentanyl produced a dose-dependent decrease in developed stress, dS dt , and time required to reach peak stress. Isolated human atrial strips responded to Innovar and the 1:1 combination of meperidine and hydroxyzine in a manner quantitatively similar to that in the rabbit papillary muscle. At concentrations of these drugs in the muscle bath comparable to measured peak serum levels in man, no change in myocardial contractility was observed.
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