Direct Microwave Synthesis ofN,N′-Diacylhydrazines and Boc-Protected Hydrazides by in situ Carbonylations under Air

Abstract

Palladium-catalyzed hydrazidocarbonylations of aryl iodides and bromides were performed by controlled microwave irradiation, employing Mo(CO)6 as a convenient CO source. A fluorous phosphine ligand was succesfully used to recycle the catalytic system. Finally, dehydration of a diacylhydrazine to the corresponding 1,3,4-oxadiazole was achieved with POCl3 in a one-pot procedure.