Abstract
A fluorescently labeled DNA molecule is end tethered to a small magnetic bead and pulled by a calibrated magnetic force through a solution of unlabeled DNA molecules to monitor the transport coefficients of the chain. From the force velocity diagram $F\ensuremath{-}V$, we report the first direct measurement of the friction coefficient $\ensuremath{\zeta}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}F/V$ of a single DNA molecule. $\ensuremath{\zeta}$ is found to be highly velocity dependent due to sharp conformational transitions for increasing velocities in agreement with a recent model by Ajdari et al. [Physica (Amsterdam) 204A, 17 (1994)].
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