Abstract
The bi-directional movement of proteins from the soma to the axon terminal is called axonal transport. Fast anterograde transport moves organelles and membrane-bound proteins distally. Fast transport rates were measured in corticospinal tract axons of male Sprague-Dawley rats by microinjection of tritiated proline into the sensorimotor cortex. Animals were killed after 3–5 h and the tract cut into 1 mm segments. A bimodal wave of radiolabeled proteins was evident, with the first peak at the spino-medullary junction and the second peak in cervical spinal segments. The fast transport rate was calculated at the leading edge of the distal wave, and found to be 303 ± 44 mm/day.
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