Abstract
The affinity between DNA and protein in sequence-specific interaction often varies depending on the superhelical density of the DNA. Small variation has been observed in, for example, the binding of bacteriophage λ repressor to its operator (Maniatis and Ptashne 1973), lactose (lac) repressor to its operator (Wang et al. 1974), and EcoRI restriction enzyme to its cognate DNA sequence (P. Modrich, pers. comm.). These variations may play an important role in the regulation of the biological functions of these proteins.
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