Abstract
The enantiomers of gemifloxacin mesylate (formerly LB20304a), a new fluoroquinolone compound with potent in vitro and in vivo antibacterial profile were resolved on a commercially available Crownpak CR chiral stationary phase (CSP). All of the fluoroquinolones, including gemifloxacin used in this study, were well enantioseperated on Crownpak CR(+) column. These results are the first reported for the direct separation of the enantiomers of quinolones on chiral crown ether coated Crownpak CR CSP. The behavior of chromatographic parameters by the change of mobile phase additives for the resolution of gemifloxacin was investigated. Also, the effect of structural change of gemifloxacin on chiral recognition was described.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
