Direct Interfacing of Neurons to Highly Integrated Microsystems

Abstract

The use of large high-density transducer arrays enables fundamentally new neuroscientific insights through enabling high-throughput monitoring of action potentials of larger neuronal networks (> 1000 neurons) over extended time to see effects of disturbances or developmental effects, and through facilitating detailed investigations of neuronal signaling characteristics at subcellular level, for example, the study of axonal signal propagation that has been largely inaccessible to established methods. Applications include research in neural diseases and pharmacology.