Direct inhibitory effect of adenosine monophosphates on Na +-K +-dependent ATPase prepared form human gastric mucosa

Abstract

Preparations of Na +-K +-dependent ATPase were obtained from human gastric mucosa and the effects of adenosine monosphosphates (cyclic 2′,3′-adrenosine monophosphate, cyclic 3′,5t́-adenosine monophosphate and 5′-adenosine monophosphate) on its activity were measured. Direct inhibitory effects of adenosine monophosphates on transport ATPase activity were found. The adenyl cyclase and transport ATPase systems are discussed.