Direct in vivo comparison of [18F]PSMA-1007 with [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-expressing xenografts

Joseph A Ioppolo,Rikki A Nezich,Kirsty L Richardson,Laurence Morandeau,Peter J Leedman,Roger I Price

doi:10.1016/j.apradiso.2020.109164

Direct in vivo comparison of [18F]PSMA-1007 with [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-expressing xenografts

Joseph A Ioppolo, Rikki A Nezich + Show 4 more

https://doi.org/10.1016/j.apradiso.2020.109164

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Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine	Publication Date: Apr 2, 2020
Citations: 14

Affiliation: Sir Charles Gairdner Hospital, Curtin University, University of Western Australia, Harry Perkins Institute of Medical Research, Queen Elizabeth II Medical Centre

#High Uptake In Bone #Uptake In Bone + Show 8 more

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Abstract

The aim of this preclinical study was to directly compare [18F]PSMA-1007 with both [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-positive tumor xenografts. Uptake was assessed by PET/CT at 1, 2 and 4 h post-injection, and by ex vivo measurement after 4 h. [18F]PSMA-1007 demonstrated the highest tumor uptake of the three tracers. The high uptake in bone for mice injected with [18F]AlF-PSMA-11 suggested rapid in vivo decomposition. This was confirmed by an in vitro plasma stability study.

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