Direct identification of parameters in a mathematical model describing conduction through the atrioventricular node

Abstract

Function of the atrioventricular node is assessed during intracardiac electrophysiology study by relating the output intervals A 2 H 2 and H 1 H 2 to the input A 1 A 2, where A and H are, respectively, atrial and His bundle electrograms recorded by catheter. The H 1 H 2 curves have been previously deduced from a model describing the A 2 H 2 curves. Because of presence in a few cases of different behaviour of A 2 H 2 and H 1 H 2, this study aimed to establish a more suitable model of H 1 H 2 independently of A 2H 2 for the particular case of a single transmission pathway. The two models were compared by calculation of standard error of the estimate. As a firt approximation, the deduced model may be sufficient. However, the standard error of the estimate was less with the direct algorithm, which is therefore the more suitable for further development, particularly for recognition and modelling of conduction over multiple pathways through the atrioventricular node.