Abstract
Copper oxide (CuO) films directly grown on Ti substrate have been successfully prepared via a hydrothermal method and used to construct an amperometric nonenzymatic glucose sensor. XRD and SEM were used to characterize the samples. The electrochemical performances of the electrode for detection of glucose were investigated by cyclic voltammetry and chronoamperometry. The CuO films based glucose sensors exhibit enhanced electrocatalytic properties which show very high sensitivity (726.9 μA mM−1 cm−2), low detection limit (2 μM), and fast response (2 s). In addition, reproducibility and long-term stability have been observed. Low cost, convenience, and biocompatibility make the CuO films directly grown on Ti substrate electrodes a promising platform for amperometric nonenzymatic glucose sensor.
Highlights
Reliable and fast determination of glucose is important in areas such as clinical diagnostics [1], biotechnology [2], and environmental and food chemistry [3], so the development of electrochemical glucose sensors has received continuous interest
All electrochemical measurements were performed on a CHI 660C electrochemical workstation (Shanghai, China) with a conventional three-electrode system composed of a platinum auxiliary, a saturated calomel electrode (SCE) reference, and CuO films grown on Ti substrate as working electrodes
Except for the peaks originating from the Ti substrate, others are the peaks of monoclinic phase of CuO (JCPDS number 89-5899) with lattice constants of a = 0.469 nm, b = 0.342 nm, and c = 0.513 nm
Summary
Reliable and fast determination of glucose is important in areas such as clinical diagnostics [1], biotechnology [2], and environmental and food chemistry [3], so the development of electrochemical glucose sensors has received continuous interest. GOx-based biosensors suffer from problems because of the disadvantages of the enzyme-modified electrodes, such as instability, high cost, complicated immobilization process, the requirement of low temperature storage, and their PH and toxic environment [5,6,7,8]. To resolve this problem, many attempts have been made to develop nonenzymatic glucose sensors in recent years. Metal oxides based glucose sensors have been widely investigated for nonenzymatic detecting due to their good stability and low cost. The good analytical performance, low cost, and one-step preparation method make this electrode material promising for the development of a nonenzymatic glucose sensor
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