Abstract
In orchidectomized rats, unilateral intrapituitary implants of micropellets containing 85% testosterone propionate (TP), 85% dihydrotestosterone benzoate (DHTB), or 2½( or 5% 7α-methyl-19-nortestosterone acetate (7αMe) acted to; 1) reverse castration cell development and 2) increase intrapituitary FSH/LH ratios (either by lowering LH or by increasing pituitary FSH concentration, or both). The effects were localized: histological changes were restricted to regions contiguous to the implants, changes in LH and FSH were more pronounced ipsilaterally than contralaterally, and accessory sex organs (seminal vesicles and ventral prostate glands) remained completely or virtually unstimulated. Similarly placed micropellets containing cholesterol or progesterone had no significant effect. Subcutaneous implantation of 3, 6, or 9 androgenic pellets failed to produce intrapituitary changes, even if enough androgen was released to stimulate the sex accessories. Subcutaneous injection of larger amounts of these androgen...
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