Direct Electrodeposition of Bimetallic Nanostructures on Co-Based MOFs for Electrochemical Sensing of Hydrogen Peroxide

Yixuan Xie,Jing Lu,Linxi Chen,Xiange Lu,Duanping Sun,Luyong Zhang,Xianhua Shi

doi:10.3389/fchem.2022.856003

Abstract

Hydrogen peroxide (H2O2) is the most significant reactive oxygen species in biological systems. Here, we reported an electrochemical sensor for the detection of H2O2 on the basis of bimetallic gold-platinum nanoparticles (Au3Pt7 NPs) supported by Co-based metal organic frameworks (Co-MOFs). First, Au3Pt7 NPs, with optimal electrocatalytic activity and accessible active surface, can be deposited on the surface of the Co-MOF–modified glassy carbon electrodes (Au3Pt7/Co-MOFs/GCE) by one-step electrodeposition method. Then, the electrochemical results demonstrated that the two-dimensional (2D) Co-MOF nanosheets as the supporting material displayed better electrocatalytic properties than the 3D Co-MOF crystals for reduction of H2O2. The fabricated Au3Pt7/2D Co-MOF exhibited high electrocatalytic activity, and the catalytic current was linear with H2O2 concentration from 0.1 μM to 5 mM, and 5–60 mM with a low detection limit of 0.02 μM (S/N = 3). The remarkable electroanalytical performance of Au3Pt7/2D Co-MOF can be attributed to the synergistic effect of the high dispersion of the Au3Pt7 NPs with the marvelous electrochemical properties and the 2D Co-MOF with high-specific surface areas. Furthermore, this sensor has been utilized to detect H2O2 concentrations released from the human Hela cells. This work provides a new method for improving the performance of electrochemical sensors by choosing the proper support materials from diverse crystal morphology materials.

Highlights

Hydrogen peroxide (H2O2), as one of the most significant reactive oxygen species (ROS), commonly exists in biological processes as a ubiquitous intracellular messenger or receptor signaling in various cells (Ushio-Fukai et al, 1999)
The result demonstrated that, with the electrodeposition time increased to 120 s, the detection signal of H2O2 reduction achieved a peak value
Vibration of the carboxyl group on the benzene ring. These results demonstrated that the pristine Co-based metal organic frameworks (Co-metal organic frameworks (MOFs)) products had been successfully synthesized

Summary

INTRODUCTION

Hydrogen peroxide (H2O2), as one of the most significant reactive oxygen species (ROS), commonly exists in biological processes as a ubiquitous intracellular messenger or receptor signaling in various cells (Ushio-Fukai et al, 1999). Few limitations are constraining the further application of these bimetallic particles-based electrochemical sensors: 1) it is usually a challenge to meet the satisfactory sensitivity of the living cells detection; and 2) their thermodynamic instability and tendency to aggregate, owing to their high surface free energy (Wang et al, 2019) These disadvantages can be improved by immobilizing metal NPs in/on supporting structures. After comparing a series ration of Au NPs and Pt NPs with (V:V = 1:9, 3: 7, 5:5, 7:3, and 9:1), a novel sensor was constructed which bimetallic Au3Pt7 NPs decorated on the 2D Co-MOF–modified glassy carbon electrode (Au3Pt7/2D Co-MOFs/GCE) by electrodeposition This high-performance electrochemical sensor was successfully utilized to monitor H2O2 concentration in real-time, and it performed a desirable property for tracing H2O2 in human cancer samples. The current response for H2O2 detection was recorded

RESULTS AND DISCUSSION

CONCLUSION

DATA AVAILABILITY STATEMENT