Abstract
The direct electrochemistry of herring sperm double-stranded DNA (dsDNA) on an ionic liquid N-butylpyridinium hexafluorophosphate modified carbon paste electrode was investigated. The cyclic voltammogram showed two irreversible oxidation peaks at 0.868 V and 1.188 V (vs. SCE), which corresponded to the oxidation of guanine and adenine residues, respectively. Compared to the common carbon paste electrode the electrochemical response was greatly improved. The electrochemical behavior of dsDNA on the modified electrode was carefully investigated with the electrochemical parameters were calculated. Under optimal conditions the dsDNA can be directly determined in the concentration range from 50 to 600 μg mL−1 with a detection limit of 17 μg mL−1 (3σ).
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