Abstract
Ketanserin (K), a 5-HT 2, α 1 and H 1 receptor antagonist, at a concentration of 5 μg/ml inhibits keratinisation, but increases DNA-, collagen and glycosaminoglycan (GAG) synthesis in embryonic chick skin in vitro. On the other hand, serotonin (S) at a concentration of 10 μg/ml stimulates keratinisation and does not enhance DNA, collagen and GAG synthesis. 5 nM doses of ketanserin and serotonin give analogous results. The effects of other 5-HT 2-receptor antagonists (e.g. BW 501 and cinanserin) are comparable to those of K, whereas prazosin (an α 1 receptor antagonist) and pyrilamin (an H 1 receptor antagonist) do not show any effect on embryonic chick skin in vitro.
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