Abstract
The direct effects of an LHRH agonist (LHRHA) on testicular interstitial fluid (IF) formation and IF levels of testosterone were studied in intact male rats aged 55-87 days. Under ether anesthesia, doses of LHRH-A ranging from 0.1-10 ng were injected into the right (R) testis, whereas the left (L) testis was injected with the injection vehicle and used to control for any peripheral effects of LHRH-A resulting from pituitary LH release. Overall control animals were injected in both R and L testes with vehicle alone. LHRH-A caused a significant (P < 0.001) and dose-dependent increase in levels of testosterone in IF from the R but not from the L (control) testis at 2-6 h after injection. With lower doses of LHRH-A (0.1-1 ng), this increase occurred in the absence of any increase in serum LH levels. In contrast, injection of 10 ng LHRH-A caused sustained LH release, and although this led to a massive increase in the IF levels of testosterone in the L (control) testis, levels in IF from the R (LHRH-A injected)...
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