Abstract
1. 1. The direct effects of l-T 3 (triiodothyronine) on glucose utilization, 2-deoxyglucose uptake and O 2 consumption were evaluated in vitro in isolated adipocytes from 6-week-old obese and nonobese Zucker rats. 2. 2. Adipocytes treated for 30 min with l-T 3 had a 20–25% decrease in glucose conversion to CO 2 fatty acids and glyceride-glycerol and uptake of 2-deoxyglucose. 3. 3. Incubation of adipocytes with either d-T 3 or rT 3 (reverse T 3) did not decrease utilization of glucose. 4. 4. T 3 also decreased the insulin-stimulated fatty acid synthesis from glucose in both obese and nonobese adipocytes. 5. 5. Adipocyte O 2 consumption was decreased by T 3 in media that contained glucose but not in media that contained either acetate or no exogenous substrate. 6. 6. These data indicate that T 3 has a direct, immediate and specific action on adipocyte glucose utilization and may act to modulate adipose lipogenesis and lipolysis.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
