Abstract
Ghrelin is an orexigenic hormone of gastric origin, and contributes to food intake and body weight regulation [1] [2]. Its postprandial secretion is attenuated by carbohydrate-rich meals [3] [4], while carbohydrate-poor food stimulates ghrelin release [5]. Gastrointestinal factors such as gastrin, somatostatin, or GLP-1 are good candidates for ghrelin inhibitors [6]. Also, there is solid evidence that insulin is a powerful inhibitor of ghrelin release in vivo [7] [8] and in vitro [6].
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