Abstract

We investigated the cellular localisation of neurofibrillary tangles in Alzheimer’s disease. All tau-positive tangles were stained for thioflavine S, while ∼84% of thioflavine S-stained tangles were tau-immunolabelled. Approximately 58–62% and 73–76% of thioflavine S- and tau-labelled tangles, respectively, were present within cortical neurons labelled for microtubule-associated protein-2. Thus, most neocortical tangles in Alzheimer’s disease are intracellular and may not be the principal cause of neocortical cell loss.

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