Abstract
In this research, direct batch and flow injection (FI) spectrophotometric methods for the analysis of piroxicam (PIX) in commercial dosage forms were investigated. The methods were based on the reaction of PIX with diazotized metoclopramide in alkaline medium to form orange color product at room temperature which absorbs maximally at λmax 472 nm. Chemical and physical variables of batch and FI methods were optimized to produce high sensitivity and reproducibility. Under the optimized experimental conditions, Beer’s law was obeyed over concentration ranges from 1 - 35 and 10 - 250 μg/mL PIX with limits of detection of 0.2 and 3.4 μg/mL and limits of quantification of 0.7 and 11.4 μg/mL PIX for batch and FI procedures, respectively. The relative standard deviation (%RSD) was less than 0.7 and 2.4 for batch and FI procedures respectively with a sample throughput of 38 h-1 for FI procedure. The proposed methods can be used for the routine analysis for the assay of PIX in injections and capsules.
 
 Bull. Chem. Soc. Ethiop. 2020, 34(1), 13-23.
 DOI: https://dx.doi.org/10.4314/bcse.v34i1.2
Highlights
Piroxicam (PIX) (C15H13N3O4S) is chemically known as 4-hydroxy-2-methyl-3-(N-pyridil-2)carboxyamido-2H,2-benzothiazine-1,1-dioxide
Diazotized metoclopramide has been used as an efficient coupling reagent in several spectrophotometric reactions [27, 28]
All the parameters that enhance the sensitivity of the diazotization reaction and the assay of PIX drug were studied
Summary
Piroxicam (PIX) (C15H13N3O4S) is chemically known as 4-hydroxy-2-methyl-3-(N-pyridil-2)carboxyamido-2H-,2-benzothiazine-1,1-dioxide. The present work describes the development of direct batch and FIA methods for the determination of PIX using another drug (metoclopramide (MP)) as a green and safe reagent.
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