Direct detection of dopamine using zinc oxide nanowire-based surface plasmon resonance sensor

Abstract

This study uses an angle interrogation approach to propose an SF11 Prism- Ag– ZnO nanowires-CeO2-Sensing layer-based surface plasmon resonance sensor. The proposed multilayer structure has been used for the concentration measurement of dopamine in human blood. The thicknesses of the ZnO nanowire (ZnO-NW) and cerium oxide (CeO2) layer have been taken as 50 nm and 0.5 nm, respectively, and the thickness of the metal layer is 50 nm considered. The characteristics and parameters are also measured for the proposed sensor. The sensitivity, full width at half maximum (FWHM), detection accuracy (DA), and quality factor (QF) are obtained as 95 deg/RIU, 14.34 deg, 0.06578 deg−1, and 6.24 RIU−1, respectively. Numerous neurological illnesses are brought on by abnormalities of dopamine (D. A.), a crucial neurotransmitter in the brain's neural circuits. Quick and sensitive sensors for D. A. detection are needed to diagnose these illnesses early. The significance of this sensor in the biomedical field.