Abstract

PurposeTo evaluate the retinal structure-function relationships in the macula of retinitis pigmentosa (RP) patients by comparing microperimetry-3 (MP-3) images with co-registered optical coherence tomography (OCT) images.MethodsThirty patients with typical RP were recruited from our hospital. The maculae of patients were examined with MP-3 and OCT. The retinal sensitivity was measured by MP-3 at 40 testing points arranged concentrically in a 16° diameter of the central retina, and we divided the 40 points into four zones according to degree from the fovea (2°, 4°, 6°, and 8°). We analyzed the correlation coefficients between the retinal sensitivity and the total retinal thickness (TRT), the length from the inner limiting membrane to the retinal pigment epithelium (RPE), and between the retinal sensitivity and the outer retinal thickness (ORT), the length from the outer plexiform layer to the RPE at each stimulus point.ResultsTRT showed moderate correlations with the retinal sensitivity at 2° (median ρ = 0.59 interquartile range (IQR) [0.38–0.72]), 4° (ρ = 0.59 [0.55–0.68]) and 6° (ρ = 0.60 [0.54–0.63]), and TRT was weakly-to-moderately related to the retinal sensitivity at 8° (ρ = 0.27 [0.19–0.48]). ORT exhibited strong correlations at 2° (ρ = 0.72 [0.60–0.81]), 4° (ρ = 0.71 [0.75–0.67]) and 6° (ρ = 0.70 [0.54–0.74]), and a weak-to-moderate correlations at 8° (ρ = 0.34 [0.29–0.53]). ORT was more strongly correlated with the retinal sensitivity compared to TRT (p = 0.018).ConclusionORT, rather than TRT, within 6° eccentricity was strongly correlated with the retinal sensitivity, suggesting that measuring ORT in those areas will help evaluate the macular status and progression in RP.

Highlights

  • Retinitis pigmentosa (RP) is a group of inherited retinal degeneration disorders characterized by the symptoms of night blindness, visual field (VF) constriction, and a subsequent decline of visual acuity in the later stage [1, 2]

  • outer retinal thickness (ORT) was more strongly correlated with the retinal sensitivity compared to total retinal thickness (TRT) (p = 0.018)

  • ORT, rather than TRT, within 6 ̊ eccentricity was strongly correlated with the retinal sensitivity, suggesting that measuring ORT in those areas will help evaluate the macular status and progression in RP

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Summary

Introduction

Retinitis pigmentosa (RP) is a group of inherited retinal degeneration disorders characterized by the symptoms of night blindness, visual field (VF) constriction, and a subsequent decline of visual acuity in the later stage [1, 2]. Macular sensitivity in retinal diseases is usually evaluated using static perimetry tests within the central 10 ̊ and more recently with the use of microperimetry devices such as the Microperimetry-3 (MP-3; Nidek Technologies, Albignasego, Italy) and the Macular Integrity Assessment (MAIA; CenterVue, Padua, Italy) [3,4,5,6,7,8,9]. These microperimetry devices have wide dynamic ranges comparable to that of a Humphrey Field Analyzer (HFA; Carl Zeiss Meditec, Dublin, CA). Microperimetry devices have been used as primary or secondary outcome measures in clinical trials for RP (https://clinicaltrials.gov)

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