Abstract
AbstractFuranose ring oxygen‐substituted artificial nucleosides show unique pharmacological activities even without incorporation into oligonucleotides, and are used as anticancer and antiviral agents. Practical synthetic routes to such nucleosides are of exceptional importance to enhance the development of (oligo)nucleotide therapeutics. Herein, we demonstrate that direct anodic N‐α hydroxylation is possible in aqueous media to realize the practical synthesis of these versatile intermediates for azanucleoside derivatives.
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