Abstract
The mechanism of nicotine-induced inhibition of pancreatic exocrine secretion of water and bicarbonate was studied, using in vitro and in vivo preparations of rabbit pancreas. High concentrations of nicotine (10 mM) in the bathing fluid of the in vitro pancreas caused decreases in flow rate, bicarbonate secretion, and tissue ATP content. In anesthetized rabbits, doses of nicotine, comparable to those absorbed by human smokers, inhibited flow and bicarbonate secretion but had no effect on tissue ATP content. Norepinephrine and epinephrine mimicked the pancreatic effects of nicotine in vivo. Phenoxybenzamine stimulated secretion of water and bicarbonate in vivo and blocked the inhibitory effects of nicotine and catecholamines. These results indicate that inhibition of pancreatic secretion by nicotine is probably mediated by release of catecholamines.
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