Abstract
This study assessed quality of life, direct and indirect healthcare costs related to ankylosing spondylitis (AS). This study included 650 prevalent AS patients visiting seven centers at tertiary healthcare institutions in Turkey who were interviewed using a standard questionnaire to determine annual direct and indirect healthcare costs. Eligible patients were age ≥18 years with AS for at least 12 months. Direct costs were categorized as inpatient, outpatient and pharmacy, and AS-related consultation. Indirect costs were categorized as workday loss, additional AS-related costs, and caregiver costs. Clinical outcome measures were obtained, including Patients’ Global Disease Activity (Pt-GDA); visual analog scale (Pain-VAS) for pain; Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Functional Index (BASFI), and Metrology Index (BASMI) scores, and EuroQoL 5 dimension (EQ-5D) health status survey scores. Mean (€4,335.20) and median (€5,671.00) annual costs per patient were calculated. Pharmacy costs (€4,032.73) were highest among overall expenditures, followed by additional AS-related consultation (€2,480.38), outpatient (€225.02), and inpatient costs (€29.98). Over half of AS patients (54.8 %) experienced work loss. Related average annual costs were €414.16, based on income level. 10.3 % of AS patients incurred an additional €2,008.07 in 1 year. 6.8 % of patients required caregivers and incurred €778.70 in average annual patient paid costs. Mean Pt-GDA, Pain-VAS, EQ-5D, BASDAI, BASFI, and BASMI scores were 4.4, 40.5, 62.7, 3.6, 3.1, and 2.9, respectively. Direct and indirect AS-related costs are high and represent a considerable economic burden on Turkish AS patients.
Highlights
Ankylosing spondylitis (AS) is a chronic, systematic, and inflammatory rheumatic disease that primarily affects the axial skeleton and can lead to structural and functional impairments, low productivity, decrease in life quality, and substantial healthcare resource use [1]
Patients’ Global Disease Activity (Pt-GDA), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Bath Ankylosing Spondylitis Metrology Index (BASMI) results are measured on a scale of 0–10, where higher scores indicate higher disease activity
Epidemiologic studies have indicated that AS is more prevalent than previously thought [17]
Summary
Ankylosing spondylitis (AS) is a chronic, systematic, and inflammatory rheumatic disease that primarily affects the axial skeleton and can lead to structural and functional impairments, low productivity, decrease in life quality, and substantial healthcare resource use [1]. Clinical features of AS include back pain, stiffness, asymmetrical peripheral oligoarthritis, and specific organ involvement such as anterior uveitis, psoriasis, and chronic inflammatory bowel disease [2]. Men are more likely to be affected compared to women at an approximate 2:1 ratio [3]. Juvenile-onset AS is usually associated with worse outcomes than adult-onset AS [4]. Surveys have estimated AS prevalence in the Turkish adult population at 0.49 % [6]
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