Abstract
In dispersed mucosal cells from guinea-pig stomach, somatostatin inhibited in a noncompetitive fashion ( K i, 2 · 10 −8 M) the increase in cellular cyclic AMP caused by histamine but not by prostaglandin E 1 or phosphodiesterase inhibitors. Somatostatin also inhibted the increase in [ 14C]aminopyrine uptake caused by low concentrations of histamine probably by interfering with the synthesis of cellular cyclic AMP.
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