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Abstract
Incubation of pieces adipose tissue in the presence of pertussis toxin (10–100 μg/ml) resulted in blockade in the isolated fat cells of the action of agents that inhibit adenylate cyclase through receptor-mediated GTP-dependent process ( α 2-adrenergic amines, prostaglandins, Ri-adenosine, niotic acid) and enhancement of the action of isoproterenol. There was a lag period of ∼ 22 h for the action of the toxin.
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