Direct a-C(sp3)-H thioetheration/selenylation of nafimidone derivatives enabled by electrocatalysis

Abstract

An effective strategy for direct α-C(sp3)-H thioetheration/selenylation of nafimidone derivatives enabled by electrocatalysis has been reported. A wide range of nafimidone, disulfide and diselenide derivatives were well compatible, giving the corresponding products in moderate to good yields. Control experiments suggested that a radical mechanism is responsible for the reaction. Such methodology not only provides a new method for the activation of C(sp3)-H bonds but also enriches the nafimidone derivatives with potential biological activity.