Abstract
The aim of the study was to prepare dipyridamole(DPM) cocrystals to alter itsphysicochemical properties as it ispoorly soluble in water, 6.8 pHbuffer and belongs to BCS class II. Cocrystals were prepared usingneat grinding method.
 Initial screening of cocrystals was done with melting point determination indicating formation of nine cocrystals. Based upon interference studies nine cocrystalswere finalized for solubility and dissolution studies. DPM-citric acid, DPM-hippuric acid, DPM-tartaric acid and DPM-oxalic acid cocrystalsshowed the significant enhancement in solubility and dissolution in 6.8 pH buffer.Further confirmation was done by DSC and PXRD studies. DPM-hippuric acid cocrystalshave shownpromising results for formation of cocrystals and considered for tablet formulation. DPM-hippuric acid cocrystal tablets were prepared by using various levels of carboxymethyl cellulose and microcrystalline cellulose. These tablets showed acceptable physical characteristics with subsequent rapid dissolution.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.