Dipole source localization and fMRI of simultaneously recorded data applied to somatosensory categorization

Abstract

In this study, the feasibility of dipole source localization (DSL) and coregistration with functional magnetic resonance imaging (fMRI) activation patterns on the basis of simultaneously acquired data is demonstrated. Brain activity was mapped during the performance of a somatosensory single reaction and a choice reaction task at high spatiotemporal resolution in six healthy subjects. The choice reaction task required a categorization of two different stimulus intensities, whereas for the single reaction task merely the perception of a tactile stimulus had to be confirmed by the subjects. An offline artifact correction algorithm was applied to 32-channel EEG data that were acquired between subsequent MRI scans. Using a multiple dipole approach, five distinct dipole sources were identified within areas of the somatosensory system. Coregistration of fMRI and DSL showed consistent spatial activation patterns with a mean distance of 9.2 ± 6.8 mm between dipole sources and fMRI activation maxima. However, since the number of fMRI activation sites exceeded the number of cerebral dipole sources, it was not possible to assign a dipole source to each fMRI activation site. Dipole moment time courses were consistent with previously reported results of similar experiments. A comparison of brain activation patterns during the two tasks with both fMRI and DSL indicated an involvement of the contralateral secondary somatosensory cortex in somatosensory categorization.