Abstract
Vaccination increase immunity against diphtheria, yet will decrease by aging. Therefore, boosters are needed to be done regularly. This study aims to determine the immunity to diphtheria for the population of 16 years old and above. The sample of study were 295 collected blood serums by Riskesdas project in 2013, the criteria was above 15 years of age and originating from the Provinces of Central Java or East Java inclusively. Immunity assessment was based on antibody titer (IgG) against diphtheria using Vero Cell cytotoxicity test. Statistical analysis was performed using the X2 test. The full protective IgG titer (>0.1 IU/ml) at the age of 16-20 years included 75% sample with a geometric mean titer (GMT) of 0.19 IU/ml. Yet, at the age of 21-60 years and > 60 years, full protective IgG titers only cover 45.5% and 33.3% sample with GMT respectively 0.06 IU / ml. Statistical analysis showed the relationship between age and immune status with p-value 0.003. Otherwise, no relationship between the status of immunity with sex and residency with p-values of 0.16 and 0.43. The immune status against diphtheria at the age of above 15 years decreases with aging.
Highlights
By 2020, the whole world is facing a major health problem, the pandemic Covid 19
This study aims to obtain a figure of immunity against diphtheria at the age of above 15 years, it will be compared to immunity at the age of
The number of diphtheria cases is significantly different between those two. It could be seen whether the differences in immune status against diphtheria were associated or not between Central Java and East Java
Summary
By 2020, the whole world is facing a major health problem, the pandemic Covid 19. other health problems must not be ignored, including diphthe-African Health SciencesVaccination policies for diphtheria may vary between countries. According to Ministry of Health, the policy for diphtheria vaccination in Indonesia requires 7 times at the age of 2 months – 3 months – 4 months – 18 months followed by at the 1st grade of elementary school, and 2nd and 5th grade. Repetition (booster) is done with DPT-HB-Hib vaccine (age 18 months), DT (grade 1 primary school) and Td (grade 2 and 5 elementary school)[7,8,9]. Vaccination increase immunity against diphtheria, yet will decrease by aging. Statistical analysis showed the relationship between age and immune status with p-value 0.003.
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