Abstract
The propagation of information inside cells is achieved in nature by small diffusible molecules. Many of these secondary messengers are highly charged species derived from myo -inositol. The diphosphoinositol polyphosphates (X-PP- myo -InsP 5 ) represent a novel group of secondary messengers that regulate various important biological processes. Depending on the phosphorylation pattern, these molecules can occur in symmetric or nonsymmetric forms. In a recent study, we have shown the potential of C 2 symmetric phosphoramidites as reagents for desymmetrizing myo -inositol and for obtaining all four possible nonsymmetric X-PP- myo -InsP 5 stereoisomers in enantiomerically pure form. These results and their potential implications for the design of tools for chemical biology are discussed.
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