Abstract
Elevated postprandial blood sugar levels were found in a forty-two-year-old Negro woman taking 400 mg. of diphenylhydantoin a day. After discontinuance of diphenylhydantoin, blood glucose levels and insulin responses were normal when oral and intravenous glucose tolerance tests and an intravenous tolbutamide test were performed. After taking 400 mg. diphenylhydantoin daily for two weeks the patient had decreased oral and intravenous glucose tolerance and an abnormal intravenous tolbutamide test with marked reduction in insulin response in all three tests. Oral glucose tolerance tests were within the limits of normal while the patient was receiving 300, 200, and 100 mg. diphenylhydantoin by mouth; however, the insulin response was decreased when the patient received 300 and 200 mg. diphenylhydantoin.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
