Diphenyl-substituted triazine derivatives: synthesis, α-glucosidase inhibitory activity, kineticsand in silico studies.

Abstract

Background: Diabetes mellitus (DM) is a chronic disorder, considered to be a major global health challenge in the 21st century. α-Glucosidase enzyme is a well-known drug target to treat Type II DM. Methods: A new library of biphenyl-substituted triazines was synthesized and confirmed by various spectroscopic techniques. Results: All compounds showed potent α-glucosidase inhibitory activity, with IC50 values ranging from 35.35±0.34 to 564.41±0.91μM, as the standard acarbose, IC50 value of 750.7±0.13μM. Our in silico study has predicted key interactions with the enzyme's active site. Drug-likeness and absorption, distribution, metabolism, excretionand toxicitywere also studied. Conclusion: This study has identified a range of potential hits against theα-glucosidase enzyme that may serve as antidiabetic agents after further investigations.