Abstract
Dipeptidyl Peptidases 8 and 9 Play Roles in Cellular Metabolism and Energy Homeostasis♦: Identifying Natural Substrates for Dipeptidyl Peptidases 8 and 9 Using Terminal Amine Isotopic Labeling of Substrates (TAILS) Reveals in Vivo Roles in Cellular Homeostasis and Energy Metabolism
Highlights
Dipeptidyl peptidase (DP) 8 and DP9 are ubiquitous intracellular exopeptidases that are highly conserved and structurally related to the extracellular type II diabetes drug target DP4
DP8 and DP9 have been implicated in immune responses and cancer; there are concerns about the possible off-target effects of DP4 inhibitors on these proteases during type II diabetes treatment
Overall at the University of British Columbia in Canada demonstrated that DP8 and DP9 are involved in cellular metabolism and energy homeostasis
Summary
Dipeptidyl peptidase (DP) 8 and DP9 are ubiquitous intracellular exopeptidases that are highly conserved and structurally related to the extracellular type II diabetes drug target DP4. Dipeptidyl Peptidases 8 and 9 Play Roles in Cellular Metabolism and Energy Homeostasisࡗ
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