Abstract
Introduction: Plaque induced periodontitis is the second most common oral disease worldwide after dental caries. Documents from animal experiments proved that NSAIDs can reduce the inflammation and the rate of resorption of alveolar bone thus, stabilize the periodontal condition. In the last 10 years, diode laser also has been highly recommended as a treatment modality for periodontal inflammatory diseases due to its anti-inflammatory effect, ability to accelerate the healing process and its pain reduction ability. Materials and Methods: 84 albino rats were divided into 4 groups. Group I is the negative control group which did not subjected to any procedure, group II is the positive control group which is subjected to ligature induced periodontitis but did not take any treatment, group III is the diode laser group which is subjected to ligature induced periodontitis and treated by diode laser irradiation after removal of the ligature and group IV is the ibuprofen group which is subjected to ligature induced periodontitis and treated by ibuprofen syrup for 4 days after removal of the ligature. Results: inflammatory cell count was measured in all specimens stained by H&E and area fraction was measured in all specimens stained by MMP-1 immuno histochemical marker. Total amount of inflammatory cells and MMP-1 decreased by time with a significant difference between treatment groups and positive control group. Conclusion: Diode laser irradiation showed greater and faster reduction in inflammation than ibuprofen.
Highlights
Plaque induced periodontitis is the second most common oral disease worldwide after dental caries
Cyclooxygenase is the critical enzyme in the formation of prostaglandin E2 from arachidonic acid .Inhibition of PGE2 synthesis by the direct inhibition of the cyclooxygenase enzyme has been achieved by non-steroidal antiinflammatory drugs (NSAIDs)
Hematoxylin and Eosin Stain: Group I (Negative Control group): The negative control group showed normal tissues, PDL fibers are well organized with normal sized interstitial tissues, and the bone is normal with resting lines
Summary
Plaque induced periodontitis is the second most common oral disease worldwide after dental caries. In the last 10 years, diode laser has been highly recommended as a treatment modality for periodontal inflammatory diseases due to its antiinflammatory effect, ability to accelerate the healing process and its pain reduction ability. These concerns are considered limiting factors for long time stability of treatment outcomes of non-surgical techniques (Saglam et al, 2014, Garcia et al, 2016). One type of high-power laser, the diode laser (DL), may reduce bacterial loads while causing few unwanted thermal side effects (Theodoro et al, 2015)
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