Abstract
Purpose: Osteoarthritis (OA) is one of the most common chronic musculoskeletal disorders, for which no effective therapeutic strategy exists. Progressive damage to the articular cartilage and bone leads to pain and loss of joint function. The development of OA is very complex, due to the dysregulation of several signaling pathways in the different tissues composing the joint, and is influenced by both genetic and environmental risk factors. OA is characterized by the loss of the stable phenotype of chondrocytes and progression towards hypertrophy.
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