Abstract
Two dinucleoside polyphosphate NAD analogs, P1-(adenosine-5′)-P3-(nicotinamide riboside-5′)triphosphate (Np3A, 1) and P1-(adenosine-5′)-P4-(nicotinamide riboside-5′)tetraphosphate (Np4A, 2), were synthesized and tested as inhibitors of both microbial and human recombinant NMN adenylyltransferase. Compounds 1 and 2 proved to be selective inhibitors of microbial enzymes.
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