Abstract
Two novel macrocyclic polyamine ligands and their dinuclear zinc (II)complexes were synthesized and characterized. Their interaction with plasmid DNA wasstudied by gel electrophoresis and fluorescence quenching experiment. The result showedthat these complexes could bind DNA efficiently under physiological conditions.
Highlights
Genetic engineering has brought new challenges and opportunities for medicine and biomedical research, whereas DNA strands would be damaged in cellular environment [1,2,3]
The synthetic route of two zinc (II) complexes with imidazolium salt bridge was shown in Scheme 1. (Boc)2O could selectively protect cyclen to obtain tri-boc-protected cyclen
The Boc-protective groups were removed by adding dropwise the solution of trifluoroacetic acid (TFA) in dichloromethane
Summary
Genetic engineering has brought new challenges and opportunities for medicine and biomedical research, whereas DNA strands would be damaged in cellular environment [1,2,3]. Imidazolium ionic liquids with cations were expected to bind DNA sequences. Imidazolium ionic liquids containing dinuclear cyclen and their zinc (II) complexes were anticipated to protect DNA strands because of their unique molecular structure. Two imidazolium ionic liquids containing dinuclear cyclen moiety and their zinc (II) complexes were first synthesized and characterized. Their interaction with pUC19 plasmid DNA was studied. The results revealed that these complexes binding with DNA showed different characteristics from previous results in our group [21,22,23] due to the cation from imidazolium moiety
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