Abstract
A unique central nervous system (CNS)-specific metalloprotease, DINE/ECEL1 (damage induced neuronal endopeptidase/ endothelin converting enzyme-like 1), has recently been added to the M13/neprilysin (NEP) family. This enzyme was identified by two groups independently using different approaches. In this review, we introduce the characteristics of DINE/ECEL1 and focus on the mechanism underlying the transcriptional regulation of DINE in response to neuronal injury.
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