Abstract
Developmental expression of calbindin-D 28K (CALB) in the medial basal hypothalamic (MBH) and amygdaloid (AMY) regions was examined by Western analysis. Males displayed significantly higher CALB levels compared to females in the MBH (but not the AMY) from gestational day 17 through postnatal day 1. These data imply that androgens or other hormonal factors regulate MBH CALB expression which in turn may modulate sexually dimorphic brain structures by preventing cell loss during neuronal development.
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