Diminished plasticity of visual function and sensory maps after cortical stroke in mice

Abstract

Event Abstract Back to Event Diminished plasticity of visual function and sensory maps after cortical stroke in mice Franziska Greifzu1*, Silvio Schmidt2, Friedrich Schmidt1, Otto W. Witte2 and Siegrid Löwel1 1 Friedrich-Schiller-University, Germany 2 University of Jena Medical School, Germany Stroke is a major cause of death and disability in the industrialized countries. It is an encouraging observation that clinically most patients who do suffer from stroke recover to some degree from the deficits which they incur. The most straightforward assumption is usually that this is due to plasticity. Many in vitro studies indicated that there is an increased plasticity in the perilesional zone of cortical infarcts. In the present study we investigated in vivo the impact of a photothrombotically induced cortical stroke on the plasticity of the neighbouring visual cortex after short periods of monocular deprivation (MD). Visual function was analyzed behaviourally with a virtual optomotor system. In addition, visual cortical maps were recorded using intrinsic signal optical imaging. After 7 days of MD, control animals showed a significant enhancement of visual acuity in the non-deprived eye and a significant ocular dominance shift towards the open eye in the optical imaging experiments. In contrast, in animals with a cortical stroke, both the enhancement of visual acuity and the ocular dominance shift were significantly lower. Thus our in vivo data rather indicate that neuronal plasticity is diminished in the surround of a cortical infarct. Conference: Bernstein Symposium 2008, Munich, Germany, 8 Oct - 10 Oct, 2008. Presentation Type: Poster Presentation Topic: All Abstracts Citation: Greifzu F, Schmidt S, Schmidt F, Witte OW and Löwel S (2008). Diminished plasticity of visual function and sensory maps after cortical stroke in mice. Front. Comput. Neurosci. Conference Abstract: Bernstein Symposium 2008. doi: 10.3389/conf.neuro.10.2008.01.052 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 14 Nov 2008; Published Online: 14 Nov 2008. * Correspondence: Franziska Greifzu, Friedrich-Schiller-University, Jena, Germany, Franziska.Greifzu@uni-jena.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Franziska Greifzu Silvio Schmidt Friedrich Schmidt Otto W Witte Siegrid Löwel Google Franziska Greifzu Silvio Schmidt Friedrich Schmidt Otto W Witte Siegrid Löwel Google Scholar Franziska Greifzu Silvio Schmidt Friedrich Schmidt Otto W Witte Siegrid Löwel PubMed Franziska Greifzu Silvio Schmidt Friedrich Schmidt Otto W Witte Siegrid Löwel Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.