Abstract
Resting breathing rate, resting end-tidal PCO 2 and ventilatory response to CO 2 were studied in patients with primary depression. Patients tended to breathe faster and showed decreased PECO 2 levels when compared with control subjects. Carbon dioxide response was determined using a modification of the rebreathing technique of Read. Endogenous depressives, unlike reactive depressives, tended to give low CO 2 responses and low CO 2 thresholds. Carbon dioxide responses of patients on admission correlated highly with severity of depression. The modification of the standard rebreathing technique, and the relationship between CO 2 response and physical and psychological variables are discussed.
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