Diminished circulating retinol and elevated α-TOH/retinol ratio predict an increased risk of cognitive decline in aging Chinese adults, especially in subjects with ApoE2 or ApoE4 genotype.

Xiaochen Huang,Yujie Guo,Nicholas Van Halm-Lutterodt,Jie Zhen,Linhong Yuan,Huiqiang Zhang,Shengqi Dong

doi:10.18632/aging.101694

Xiaochen Huang, Yujie Guo + Show 5 more

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https://doi.org/10.18632/aging.101694

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Abstract

Objective: The current study evaluated the relationship between circulating fat soluble vitamin status and cognition in aging Chinese population.Methods: A cross-sectional study was carried out in 1754 community residents aged 55-80 years aiming to evaluate the relationship between circulating α-tocopherol and retinol status and cognition. The effect of ApoE genetic polymorphism on the relationship between vitamins and cognition was also explored.Results: Our results indicated that serum retinol status positively correlated with cognitive performance; while, serum α-tocopherol (α-TOH)/retinol ratio negatively correlated with cognitive performance. Mild cognitive impairment (MCI) subject demonstrated higher serum α-TOH status (P < 0.05), α-TOH/retinol ratio (P < 0.01) and lower retinol status (P < 0.01) than normal subjects. Subjects with ApoE4 genotype have lower serum retinol level (P < 0.05) and higher α-TOH/retinol ratio (P < 0.01) than subjects with ApoE3 genotype. MCI-ApoE4 carriers demonstrated the worst cognitive performance (P < 0.05) and exhibited higher serum TC, α-TOH and α-TOH/retinol ratio levels (P < 0.05), and lower LDL-C, retinol and lipid-adjusted retinol status (P < 0.05). MCI-ApoE2 subjects showed higher serum TC, HDL-C content and α-TOH/retinol ratio (P < 0.05); and lower serum retinol and lipid-adjusted retinol status (P < 0.05).Conclusion: Lower circulating retinol and higher α-TOH/retinol ratio potentially predicts an increased risk for the development of cognitive decline in aging Chinese adults. ApoE2 or E4 carriers with higher circulating α-TOH/retinol ratio infer poor cognitive performance and an increased risk of developing MCI.

Highlights

IntroductionVitamin A (VA) and vitamin E (VE) play essential roles in maintaining normal brain function [1]
As powerful antioxidants, vitamin A (VA) and vitamin E (VE) play essential roles in maintaining normal brain function [1]
Our results indicated that serum retinol status positively correlated with cognitive performance; while, serum α-tocopherol (α-TOH)/retinol ratio negatively correlated with cognitive performance

Summary

Introduction

Vitamin A (VA) and vitamin E (VE) play essential roles in maintaining normal brain function [1]. Growing number evidences indicate that greater dietary intake of VA and VE is associated with substantial reductions in AD risk; while, lesser intake of VA and VE may potentially contribute to neurodegeneration with an increased risk of acquiring AD [2]. Animal-based experimental and population-based epidemiology studies have extensively highlighted the importance of maintaining optimal VA and VE. N (Yes, %) Reading habit, n (Yes, %) AD family history, n (Yes, %). Female BMI (kg/m2), mean ± SD Education, n (%). Junior college Undergraduate and above Life style Physical activity, n (%)

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