Diminished adherence of sickle erythrocytes to cultured vascular endothelium by piracetam.

Abstract

Erythrocytes from both normal and sickle cell donors were incubated on a bed of cultured rat vascular endothelial cells. Although the adherence of the erythrocytes to the endothelial cells was equivalent for both classes of donor, addition of 1.5 mM piracetam significantly decreased this adherence regardless of donor.