Dimensions of Niche-Induced Anti-Apoptosis of Therapeutically Resistant Neoplasms in Radio-Chemo-Therapy

Abstract

It is proposed that apoptotic linear progression schemes do not adequately account for the emergence of non response in radio chemoresistant neoplastic lesions In such defining contributory patterns of activated and non activated apoptosis there is emerging evidence for distributional programs sustained by networks of spatial distribution Such a concept may well implicate angiogenic switches and origins of vessels and tumor cells from a resident stem cell population in the niche micro environment It is towards the realization of performance attributes of cell cycle arrest on the one hand and of proliferative dysfunctionality that the resistance and relapse of tumors is exemplified by an integrated clonogenic phenomenon of cellular derivation and end result as relapsed neoplasms