Dimensional changes of the maxillary sinus augmented with a collagenated synthetic bone block or synthetic bone particulates: A pre‐clinical study in rabbits

Abstract

To compare the efficacy of a collagenated synthetic bone substitute (C-SBS) to a particulated synthetic bone substitute (P-SBS) in volume maintenance and new bone formations in a rabbit sinus model. Either C-SBS or P-SBS was grafted in both sinuses of 16 rabbits. Four (N=8) or 12 (N=8) weeks after the surgery, total augmented volume (TAV) and area (TAA), as well as new bone volume (NBV) and area (NBA), were statistically compared by radiographic and histomorphometric analyses (p<.05). The differences in TAV, NBV, TAA and NBA between C-SBS and P-SBS groups at 4weeks were not statistically significant. The TAV (267.13±62.08 vs. 200.18±40.32mm3 ) and NBV (103.26±10.50 vs. 71.10±7.58mm3 ) in group C-SBS were significantly higher than in group P-SBS at 12weeks (p<.05). The TAA (19.36±2.88 vs. 14.48±2.08mm2 ) and NBA (5.43±1.20 vs. 3.76±0.78mm2 ) in group C-SBS were significantly higher than in group P-SBS at 12weeks (p<.05). Collagenated synthetic bone substitute grafted in rabbit sinuses demonstrated more favourable outcomes across all outcome measures compared to P-SBS at 12weeks.