Abstract
Dilutional acidosis following hetastarch or albumin in healthy volunteers
Highlights
The fact that inadequate fluid resuscitation results in a lactic acidosis is well established
The impact on acid base balance of the colloid solutions commonly used in this setting is less well established
The administration of normal saline is known to produce an acidosis and has been theorised to be a result of dilution of bicarbonate. If this theory is correct, there should be no difference in acid base changes resulting from different fluid infusions
Summary
The fact that inadequate fluid resuscitation results in a lactic acidosis is well established. The impact on acid base balance of the colloid solutions commonly used in this setting is less well established. The administration of normal saline is known to produce an acidosis and has been theorised to be a result of dilution of bicarbonate. If this theory is correct, there should be no difference in acid base changes resulting from different fluid infusions. The aim of the study was to document the acid base changes following infusion of colloid solutions and to try to establish the mechanism responsible
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