Dilated cardiomyopathy in multicore myopathy

Abstract

Multicore myopathy is a skeletal muscle disorder causing proximal skeletal muscle weakness. The typical feature on skeletal muscle biopsy is the presence of multiple small cores within muscle fibers from which mitochondrial enzymes are absent by enzyme histochemistry. The occurrence of cardiac disease in patients with multicore myopathy has only recently been described, 1 and descriptions of the cardiac pathology are rare. We report the findings at necropsy in a man with multicore myopathy and a long history of biventricular congestive heart failure.