Abstract
Nicolau syndrome is a rare and local complication of aberrant intramuscular injections of various drugs. It is characterized by a necrotic or hemorrhagic plaque, which follows a pale then consequently an erythematous macule on the injection area. It usually heals by leaving an atrophic scar. The exact pathogenesis is unknown. Nonetheless, a possible cause is the development of arterial spasm following tissue necrosis after the drug is injected into a blood vessel by mistake. Here, we presented a case of Nicolau syndrome occurring after the injection of diclofenac to the thigh region.
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